Doloteffin – clinically proven excellent tolerance

Doloteffin is clearly better tolerated than a synthetic painkiller 1

Study drop-outs

Reasons for dropping out

Synthetic Cox-II Inhibitor:

  • Stomach pain (AE)
  • Back pain too intense
  • Abdominal complaints (AE)
  • Viral infection, stomach disorder (AE)
  • Nausea, abdominal complaints after taking Tramadol (AE) 
  • Hypertension, vertigo, uneasiness (AE) 
  • No sufficient pain relief
  • Diarrhoea (AE) 


  • Stomach pain, stomach cramps (AE)

AE: Adverse event


Doctors and patients judge the tolerance as good or excellent 2

Assessment of tolerance* by the doctors and patients at the end of treatment

1. Chrubasik et al. Rheumatology 2003; 42:141-148
2. Wegener and Lüpke, Phytotherapy Research 2003; 17:1165-1172.