In-vitro study on Doloteffin

Antiinflammatory effect of Devil’s claw

• Inhibition of the secretion of pro-inflammatory cytokines by LPS-stimulated monocytes, e.g. cytokines IL-1ß, IL-6 and TNF-α.
• IL-1ß seems to play a special role in the pathogenesis of rheumatic diseases.

The inhibition of IL-1ß by watery extracts of Devil‘s claw roots is apparently more pronounced than by alcoholic extracts.*

* Fiebich BL, Heinrich M, Hiller K-O, Kammerer N. Inhibition of TNF-α synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 2001;8:28–30.
Fiebich B., Krammerer N. Antiinflammatory effects of of Harpagaphytum lysates. Phytomedicine 2000; 7 (Suppl II):40.
Chrubasik S, Fiebich B, Black A, Pollak S. Treating low back pain with an extract of Harpagophytum that inhibits cytokine release. Eur J Anaesthesiol. 2002;19:209.

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