Doloteffin – clinically proven excellent tolerance
Doloteffin is clearly better tolerated than a synthetic painkiller 1
Study drop-outs

Reasons for dropping out
Synthetic Cox-II Inhibitor:
- Stomach pain (AE)
- Back pain too intense
- Abdominal complaints (AE)
- Viral infection, stomach disorder (AE)
- Nausea, abdominal complaints after taking Tramadol (AE)
- Hypertension, vertigo, uneasiness (AE)
- No sufficient pain relief
- Diarrhoea (AE)
Doloteffin:
- Stomach pain, stomach cramps (AE)
AE: Adverse event
Doctors and patients judge the tolerance as good or excellent 2
Assessment of tolerance* by the doctors and patients at the end of treatment


1. Chrubasik et al. Rheumatology 2003; 42:141-148
2. Wegener and Lüpke, Phytotherapy Research 2003; 17:1165-1172.
